'Osmosin': a multi-centre evaluation of a technological advance in …
WEBA multi-centre, double-blind trial was carried out in 272 out-patients with osteoarthritis of the knee(s) to compare the efficacy and tolerability of 'Osmosin', the osmotic release system for indomethacin (7 mg per hour for approximately 10 hours), with that of conventional indomethacin capsules (25 …
Osmotic-controlled release oral delivery system - Wikipedia
WEBThe osmotic-controlled release oral delivery system (OROS) is an advanced controlled release oral drug delivery system in the form of a rigid tablet with a semi-permeable outer membrane and one or more small laser drilled holes in it.
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WEBThe oral osmotic tablet is designed to release the constituent drug molecules in a controlled and predetermined fashion through the principles of osmosis, which encompasses the movement of solvent molecules across a semipermeable membrane with the aid of concentra-tion gradients [8].
'Osmosin': a multi-centre evaluation of a ... - Semantic Scholar
WEBThe results, as assessed by the subjective and objective clinical variables and laboratory parameters studied, showed that 'Osmosin' provided not only comparable overall therapeutic response but also a preferable tolerability profile to …
Osmosin: its effect on plasma and synovial fluid kinetics of ...
WEB‘Osmosin’ (sodium indomethacin trihydrate, now withdrawn) produced a constant rate of release of indomethacin into the gut. Paired plasma and synovial fluid samples were obtained at regular intervals following a single dose of ‘Osmosin’ (19 patients) and after continuous daily dosing (15 patients).
Osmotic-controlled release oral tablets: technology and functional ...
WEBOct 21, 2021 · Osmotic tablets are a special type of controlled-release dosage form that offers additional benefits. Unlike conventional controlled release, osmotic tablets are insensitive to various physiological factors that result from food intake, gastric pH, and patient-to-patient variability.
Biopharmaceutical evaluation of ‘Osmosin’ - Taylor & Francis Online
WEB‘Osmosin’ is an osmotically-controlled oral drug delivery system which presents a saturated solution of sodium indomethacin trihydrate (105.4 mg), equivalent to 8.5 mg indomethacin, to the gastro-intestinal tract at a constant rate of 7 mg per hour, with a release time of 10 to 12hours.
‘Osmosin’: A multi-centre evaluation of a technological advance in …
WEBAug 26, 2008 · The results indicate that ‘Osmosin’ given once daily is a well-tolerated and efficacious therapy for patients with osteoarthritis. Key Words:: Indomethacin. dosage forms. ‘Osmosin’. osteoarthritis. Reprints and Corporate Permissions.
Points : Recommended dose of Osmosin - National Center for ...
WEBSep 9, 1983 · Rhymer AR, Sromovsky JA, Dicenta C, Hart CB. 'Osmosin': a multi-centre evaluation of a technological advance in the treatment of osteoarthritis. Curr Med Res Opin. 1983; 8 (Suppl 2):62–71. [Google Scholar]
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